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International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency

Identifieur interne : 009516 ( Main/Exploration ); précédent : 009515; suivant : 009517

International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency

Auteurs : Stuart M. Lichtman [États-Unis] ; Hans Wildiers [Belgique] ; Vincent Launay-Vacher [France] ; Christopher Steer [Australie] ; Etienne Chatelut [France] ; Matti Aapro [Suisse]

Source :

European journal of cancer : (1990) [ 0959-8049 ] ; 2007.

RBID : Pascal:07-0083889

Descripteurs français

Pascal (Inist)
- Tumeur maligne, International, Gériatrie, Cancer rein, Cancérologie, Recommandation, Insuffisance rénale, Posologie, Personne âgée, Créatinine, Clairance, Sérum, Pharmacologie.
Wicri :
- topic : Recommandation, Personne âgée, Pharmacologie.

English descriptors

KwdEn :
- Cancerology, Clearance, Creatinine, Elderly, Geriatrics, International, Kidney cancer, Malignant tumor, Pharmacology, Posology, Recommendation, Renal failure, Serum.

Abstract

A SIOG taskforce was formed to discuss best clinical practice for elderly cancer patients with renal insufficiency. This manuscript outlines recommended dosing adjustments for cancer drugs in this population according to renal function. Dosing adjustments have been made for drugs in current use which have recommendations in renal insufficiency and the elderly, focusing on drugs which are renally eliminated or are known to be nephrotoxic. Recommendations are based on pharmacokinetic and/or pharmacodynamic data where available. The taskforce recommend that before initiating therapy, some form of geriatric assessment should be conducted that includes evaluation of comorbidities and polypharmacy, hydration status and renal function (using available formulae). Within each drug class, it is sensible to use agents which are less likely to be influenced by renal clearance. Pharmacokinetic and pharmacodynamic data of anticancer agents in the elderly are needed in order to maximise efficacy whilst avoiding unacceptable toxicity.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">A SIOG taskforce was formed to discuss best clinical practice for elderly cancer patients with renal insufficiency. This manuscript outlines recommended dosing adjustments for cancer drugs in this population according to renal function. Dosing adjustments have been made for drugs in current use which have recommendations in renal insufficiency and the elderly, focusing on drugs which are renally eliminated or are known to be nephrotoxic. Recommendations are based on pharmacokinetic and/or pharmacodynamic data where available. The taskforce recommend that before initiating therapy, some form of geriatric assessment should be conducted that includes evaluation of comorbidities and polypharmacy, hydration status and renal function (using available formulae). Within each drug class, it is sensible to use agents which are less likely to be influenced by renal clearance. Pharmacokinetic and pharmacodynamic data of anticancer agents in the elderly are needed in order to maximise efficacy whilst avoiding unacceptable toxicity.</div>
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International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency

International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri